Group Members

View Current Members or Alumni

Principal Investigator

 

Silvia Cavagnero

silvia.chem.wisc.edu
Telephone Number: Tel: (608) 262-5430. Fax: (608) 262-9918
Address: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Room # 5351, Madison, WI 53706.

Education:
Ph.D. 1996, California Institute of Technology
M.S. 1990, University of Arizona
B.S. 1988, 'La Sapienza' University, Rome, Italy

Teaching:
-Biophysical Chemistry (Chem/Biochem 565/665)
-Biophysical Spectroscopy (Chem 668)
-Physical Chemistry (Chem561)
-Principles of Multidimensional NMR Spectroscopy (Chem 860)
-General Chemistry (Chem 103, Chem 104)
-Physical Chemistry Laboratory (Chem 563, 564, 567)

Hobbies / Interests:
Drawing, painting, curved origami, and spending time with Irene & Cecilia

Graduate Students

  Rayna

Rayna Addabbo

raynaaddabbo@gmail.com

Joined Group:
September, 2011

Education:
BS in Chemistry, Rutgers University, New Brunswick, NJ

Home Town:
Teaneck, NJ

Research before joining the lab:
Studies on the protein collagen in Dr. Jean Baum's research group (Rutgers University)

Current research Project:
Cotranslational protein folding studies using fluorescence

Hobbies / Interests:
Music and reading

  Yusuke

Yusuke Okuno

okuno@wisc.edu

Joined Group:
September, 2011

Education:
BS Molecular and Cellular Biology, and Chemistry at University of Illinois at Urbana-Champaign

Home Town:
Shiga, Japan

Research before joining the lab:
DNA recombination and mismatch repair proteins

Current research Project:
Investigating enhancement in NMR sensitivity by photo-chemically induced dynamic nuclear polarization

Hobbies / Interests:
Music

  Angela

Angela Varela

aevarela@wisc.edu

Joined Group:
October, 2012

Education:
B.S. in Biology from Northeastern Illinois University (NEIU)

Home Town:
Chicago, Ill

Previous work experience:
Studied the design of an infrared fluorescent tissue marker for in Vivo imaging in mammals in Dr. Emina A. Stojkovic's lab at NEIU.

Current research Project:
Elucidate the roles of protein net charge and hydrophobicity in protein folding

Hobbies / Interests:
Reading, watching movies, shopping

  Andrew

Andrew Fuchs

afuchs@chem.wisc.edu

Joined Group:
February, 2013

Education:
BS in Cellular Biology and Physiology at University of Wisconsin - Whitewater

Home Town:
Cedarburg, WI

Research before joining the lab:
-Toxicity of select pharmaceuticals and personal care products (PPCPs) on freshwater macroinvertebrates.
-Effect of estrogenic wastewater treatment plant effluent on fathead minnow (Pimephales promelas) mating pairs.

Current Research Project:
Using fluorescence resonance energy transfer (FRET) to study the folding pathway of the N-terminal SH3 domain of the protein drk.

Hobbies / Interests:
Frisbee golf, ultimate frisbee, running, lifting weights, reading, building computers, cooking, canoeing, drawing

  Matt

Matthew Dalphin

dalphin@wisc.edu

Joined Group:
January, 2015

Education:
B.S. in Biochemistry with honors at California State University, Fullerton

Home Town:
Oceanside, CA

Research before joining the lab:
Identifying novel copper-binding proteins in mammalian blood plasma (Dr. Maria Linder, 2013-2014 CSU Fullerton HHMI Research Scholar). Production and characterization of amyloidogenic human cystatin C. (Dr. Regina Murphy, 2013 Univ. of Wisconsin- Madison Summer Research Program).

Current research Project:
Characterizing the impact of co-translational nascent chain interactions on protein folding.

Hobbies / Interests:
Hiking, Camping, Music, Cooking

  Miranda

Miranda Mecha

mmecha@wisc.edu

Joined Group:
September, 2015

Education:
B.S. in Biochemistry at Carroll University

Home Town:
Milwaukee, Wi

Research before joining the lab:
Record lab: Focused on the mechanism of RNAP’s open complex formation. Studied the FRET kinetics of fluorescently labeled promoters on the stopped-flow instrument and rapid-quench association assays with radioactively labeled DNA using a 3-syringe fast-mixer. Also conducted dissociation assays to determine optimal conditions for hydroxyl-radical footprinting.

Current research Project:

Determining the folded state of SH3 as it is released from DnaK using stopped flow fluorescence and Circular Dichroism (CD) detection.

Hobbies / Interests:
Reading, writing, cooking, and Netflix

 

Hanming Yang

hyang366@wisc.edu

Joined Group:
November, 2016

Education:
University of Colorado, Boulder as undergraduate major in chemistry

Previous research before joining the lab

High-resolution IR spectroscopy on small organic radicals

Current Project

Sensitivity enhancement in NMR spectroscopy by photochemically induced dynamic nuclear polarization

Hobbies / interesets: 

Cycling, Skiing, cat petting.

 

Hao-Che Wang

hwang593@wisc.edu

Joined Group:
December, 2016

Education:
M.S. in Molecular and Cellular Biology at National Taiwan University

Research before joining the lab:

The Study of Polyribosome effect on programed -1 ribosomal frameshifting

Current research project: 

Conformation of ribosome-bound nascent proteins

Hobbies / interesets: 

Play the piano, watch movies, Reading, Cooking

Undergraduate Students

  Teddy

Teddy Jennaro

tjennaro@wisc.edu

Joined Group:
May, 2013

Education:

Home Town:
New Berlin, WI

Current research project:
Co-translational protein folding through computational analysis and fluorescence resonance energy transfer (FRET).

Hobbies / Interests:
Soccer, tennis, football, fishing, reading, cooking, listening to music

  Aniruddha

Aniruddha Srivastava

asrivastava5@wisc.edu

Joined Group:
May, 2014

Education:

Home Town:
Wausau, WI

Current research project:
Studying the thermodynamic stabilities and unfolding kinetics of ribosomal-bound nascent chains

Hobbies / Interests:
Soccer, lacrosse, reading, traveling, sushi

  Andy

Andrew Wittman

ajwittman@wisc.edu

Joined Group:
January, 2015

Education:

Home Town:
Marshfield, WI

Current research project:
Studying the effect of previously formed secondary structuctural elements on the structure of a denatured protein.

Hobbies / Interests:
Football, Hockey, Badger Athletics, Traveling, Computers and Technology

 

Susanna Yaeger-Weiss

yaegerweiss@wisc.edu

Joined Group:
January, 2015

Education:

Home Town:
Sun Prairie, WI

Current research project:
Protein folding as a function of chain elongation using computational analysis

Hobbies / Interests:
Reading, music, violin, biking

 

Collin goebel

cpgoebel@wisc.edu

Joined Group:
March, 2015

Education:

Home Town:

Mequon, WI

Current research project

Investigating the role of the DnaK chaperone in the folding of the SH3 client protein

Hobbies / Interests:

Tennis, biking, football, reading

 

Andrew Stangl

ajstangl@wisc.edu

Joined Group:
May, 2015

Education:

Home Town:

Sauk City, WI

Current research project:

Investigating the kinetic trapping of proteins in an aggregated state.

Hobbies / interests:

Snowboarding, long boarding, audiobooks, fishing, hunting.

 

Tess Carlson

tcarlson4@wisc.edu

Joined Group:
January, 2016

Education:

Current research project:

Single-molecule confocal instrumentation to understand protein conformational changes

Hobbies / interests:

Traveling, Movies, Coffee

 

Yoo Jin Song

song93@wisc.edu

Joined Group:
June, 2016

Education:

Home Town:
Seoul, Republic of Korea

Started in lab:

June 2016

Current research project:

Computational analysis on kinetic and thermodynamic behavior of protein translation, folding, aggregation and interaction with molecular chaperones

Hobbies / Interests:
Cooking, movies, music, painting, flute, tennis, running.

 

Natalie Feider

nfeider@wisc.edu

Joined Group:
January, 2017

Education:

Current research project:

Cell growth and protein purification of molecular chaperones and client proteins

Hobbies/interesets outside of lab:

Music, Art, Movies

 

Jael Garamendi

jgaramendi@wisc.edu

Joined Group:
January, 2017

Education:

Current research project:

Viscosity and fluorescence measurement in the cell environment

Hobbies / interests:

Pilates and Movies

 

Alex Staikos

staikos@wisc.edu

Joined Group:
January, 2017

Education:

Research before joining lab:

Effects of RNF113a1/a2 expression in N2A cells

 

Current research project:

Purification of fluorophore-labeled tRNA
Hobbies/Interests outside of lab:

Music, running