Group Members

View Current Members or Alumni

Principal Investigator

 

Silvia Cavagnero

cavagnero@chem.wisc.edu
Telephone Number: Tel: (608) 262-5430. Fax: (608) 262-9918
Address: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Room # 5351, Madison, WI 53706.

Education:
Ph.D. 1996, California Institute of Technology
M.S. 1990, University of Arizona
B.S. 1988, 'La Sapienza' University, Rome, Italy

Teaching:
-Biophysical Chemistry (Chem/Biochem 565/665)
-Biophysical Spectroscopy (Chem 668)
-Physical Chemistry (Chem561)
-Principles of Multidimensional NMR Spectroscopy (Chem 860)
-General Chemistry (Chem 103, Chem 104)
-Physical Chemistry Laboratory (Chem 563, 564, 567)

Hobbies / Interests:
Drawing, painting, curved origami, and spending time with Irene & Cecilia

Research Scientist

 

Valeria Guzman-Luna

vguzman.luna@gmail.com

Education:
B.S. 2005, National Autonomous University of Mexico (UNAM), Mexico City, Mexico
Ph.D. 2012, National Autonomous University of Mexico (UNAM), Mexico City, Mexico

Joined Group:
January, 2019 (Research Scientist)

January, 2014 (Postdoctoral Researcher)

Home Town:
Mexico city, Mexico

Research before joining the lab:
Studies on the protein folding in vitro, protein stability and protein directed evolution

Current research Project:

Cotranslational protein folding studies using fluorescence.

Interactions between ribosome nascent chains and the ribosome surface.

Hobbies / Interests:
Playing soccer, yoga and meditation.

Graduate Students

  Miranda

Miranda Mecha

mmecha@wisc.edu

Joined Group:
September, 2015

Education:
B.S. in Biochemistry at Carroll University

Home Town:
Milwaukee, Wi

Research before joining the lab:
Studying the mechanism of RNAP’s open complex formation fia FRET and  hydroxyl-radical footprinting.

Current research Project:

Determining the folded state of SH3 as it is released from DnaK using steady state and time-resolved fluorescence signal and fluorescence anisotropy, as well as stopped-flow fluorescence and Circular Dichroism (CD).

Hobbies / Interests:
Reading, reviewing books, baking, spending time with my dog.

 

Hanming Yang

hyang366@wisc.edu

Joined Group:
November, 2016

Education:
B.S. Chemistry, University of Colorado-Boulder, Boulder, CO

Research before joining the lab

High-resolution IR spectroscopy of small, organic radicals

Current Project

Sensitivity enhancement in NMR spectroscopy using Photochemically Induced Dynamic Nuclear Polarization (photo-CIDNP)

Hobbies / Interests: 

Cycling, Skiing, cat petting

 

Rachel Hutchinson

rhutchinson3@wisc.edu

Joined Group:
November, 2017

Education:
B.S. in Chemistry and Mathematics at Roberts Wesleyan College

Home Town:
Cortland, NY

Research before joining the lab:
-Studied the absorption of CdTe quantum dots onto TiO2 films (Dr. David Watsons's lab, Universiity of Buffalo)
-Compared activities of pyridine-carboxylate iridium catalysts for water oxidation (Dr. Alceo MMacchioni's lab, University of Perugia, Italy)
 

Current Research Project:
Single molecule FRET to study co-translational protein folding on the ribosome.

Hobbies / Interests:
Running and reading

 

Meranda Masse

mmasse@wisc.edu

Joined Group:
November, 2017

Education:
B.S. Chemistry and Environmental Science, Alverno College, Milwaukee, WI

Home Town:
Antioch, Illinois

Previous research before joining the lab:
Studied the relationship between microbial sulfur metabolism and Iron (III) reduction to elucidate the evolutionary history and biodiversity of microbial respiratory systems

Current Project:
Studying the thermodynamic interplay between ribosomes and nascent chains and solving high-resolution structures of RNC's using single-particle cryo-electron microscopy.

Hobbies / Interests: 
Yoga, rock climbing, reading and biking. I also have two dogs (Lincoln and Toby) that I love to spend time with.

 

Justin Dang

hhdang@wisc.edu

Joined Group:
December, 2019

Education:
B.S. Chemistry and Mathematics, Stetson University, Deland, FL.

Home Town:
Ho Chi Minh City, Vietnam

Previous research before joining the lab:
Investigating the role of Src-Kinase in rapid endocytosis in mouse hippocampal tissues with fluorescence optical imaging (Dr. Jianhua Xu Lab, Department of Neuroscience, Augusta University).

Current Project:
Exploring protein folding and aggregation during the early stages of protein life.

Hobbies / Interests: 
Running, cooking different culture cuisines, trying out different hair colors, anime, Đam my~ and Kpop.

 

Shaneen Britton Acevedo

brittonaceve@wisc.edu

Joined Group:
December, 2020

Education:
B.S. Biochemistry and Molecular Biology, University of California, Santa Cruz, CA

Home Town:

Bluefields, Nicaragua & Richmond, CA

Previous research before joining the lab:
Purification and structural characterization of mutant AgRP and investigation of it’s role in increasing appetite by its interactions with the Melanocortin system. (Dr.Glenn Millhauser’s Lab, Department of Chemistry, University of California Santa Cruz)

Current Project:
TBE.

Hobbies / Interests: 
Reading, netflix, hiking, sailing, paddle boarding, and kayaking. I want to learn to run, and bike.

 

Clayton Mickles

mickles@wisc.edu

Joined Group:
December, 2020

Education:
B.A. Biological Chemistry and Physics, Grinnell College, Grinnell, IA

 

Home Town:
Aspen, CO

 

Previous research before joining the lab:
EXSY studies of T1 relaxation time constants of platinum phosphine complexes (Dr. T. Andrew Mobley Lab, Department of Chemistry, Grinnell College).

Current Project:
Optimization of LC-Photo-CIDNP using Selectively Labelled Tryptophan.

Hobbies / Interests: 
Reading (specifically Science Fiction and Fantasy), video games, classic rock, anime, and singing.

Undergraduate Students

 

Jasmine Machhi

machhi2@wisc.edu

Education:

Joined Group:
January, 2020

Home Town:
Mequon, Wisconsin

Current research Project:

Studying the conformational changes client proteins experience through the molecular chaperone cycle 

Hobbies / Interests:
Traveling, music, and reading.

 

Wanting Wei

wwei54@wisc.edu

Education:

Joined Group:
June, 2019

Home Town:
Beijing, China

Current research Project:

Exploring nascent chain interactions with the ribosomal surface.

Hobbies / Interests:
Cooking and playing with pets.

 

Gordon Winkler

glwwinkler19@gmail.com

Education:

Joined Group:
January, 2020

Home Town:
Truro, Massachusetts.

Current research Project:

Kinetic trapping in eukaryotic cells.

Hobbies / Interests:
Sailing and skiing.

 

Ningkun Zhou

nzhou36@wisc.edu

Education:

Joined Group:
January, 2020

Home Town:
Huizhou, China

Current Research Project:

Studying ribosome-bonded proteins chains by using single-molecule fluorescence.

Hobbies / Interests:

traveling, movie, music

 

Kevin England

kengland@wisc.edu

Joined Group:
January, 2018

Education:

Current Project:

Investigating protein thermostability 

Hobbies / Interests:

Canoeing, backpacking, skiing

 

Anna Allen

ajallen2@wisc.edu

Joined Group:
January, 2019

Education:

Current research project:

Reengineering the E. coli ribosome to reduce inclusion body formation in overexpression conditions. 

Hobbies / Interests:

Running, traveling, music, foreign languages

 

 

 

 

Chelsea Chen

xchen783@wisc.edu

Joined Group:
January, 2019

Education:

Current research project:

Viscosity measurements to study compaction of ribosome-bound nascent peptide chains.

Hobbies / Interests:

Traveling, running, trying new food, calligraphy and photography.

 

 

 

Janotha Zachary

zjanotha@wisc.edu

Joined Group:
January, 2021

Education:

Joined Group:
January 2021.

Home Town:
Oshkosh, Wisconsin.

Current research Project:
Investigating protein folding state as a function of pH using amino acid sequences.

Hobbies / Interests:
Running, playing guitar, snowboarding, hiking and waterskiing.

 

 

 

Lucas Bartel

lebartel@wisc.edu

Joined Group:
May, 2021

Education:

Joined Group:
May 2021

Home Town:
Salt Lake City, Utah

Current research Project:
To be determined.

Hobbies / Interests:
Board games, languages, and cooking.