Group Members

View Current Members or Alumni

Principal Investigator

 

Silvia Cavagnero

cavagnero@chem.wisc.edu
Telephone Number: Tel: (608) 262-5430. Fax: (608) 262-9918
Address: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Room # 5351, Madison, WI 53706.

Education:
Ph.D. 1996, California Institute of Technology
M.S. 1990, University of Arizona
B.S. 1988, 'La Sapienza' University, Rome, Italy

Teaching:
-Biophysical Chemistry (Chem/Biochem 565/665)
-Biophysical Spectroscopy (Chem 668)
-Physical Chemistry (Chem561)
-Principles of Multidimensional NMR Spectroscopy (Chem 860)
-General Chemistry (Chem 103, Chem 104)
-Physical Chemistry Laboratory (Chem 563, 564, 567)

Hobbies / Interests:
Drawing, painting, curved origami, and spending time with Irene & Cecilia

Research Scientist

 

Valeria Guzman-Luna

vguzman.luna@gmail.com

Education:

Ph.D. 2012, National Autonomous University of Mexico (UNAM), Mexico City, Mexico

B.S. 2005, National Autonomous University of Mexico (UNAM), Mexico City, Mexico

Joined Group:

January, 2019 (Research Scientist)

January, 2014 (Postdoctoral Researcher)

Home Town:

Mexico city, Mexico

Research before joining the lab:

Studies on the protein folding in vitro, protein stability and protein directed evolution

Current research Project:
Cotranslational protein folding studies using fluorescence

Interactions between ribosome nascent chains and the ribosome surface

Hobbies / Interests:

Playing soccer, yoga and meditation

Graduate Students

  Andrew

Andrew Fuchs

afuchs@chem.wisc.edu

Joined Group:
February, 2013

Education:
B.S. in Cellular Biology and Physiology at University of Wisconsin - Whitewater

Home Town:
Cedarburg, WI

Research before joining the lab:
-Toxicity of select pharmaceuticals and personal care products (PPCPs) on freshwater macroinvertebrates.
-Effect of estrogenic wastewater treatment plant effluent on fathead minnow (Pimephales promelas) mating pairs.
-Solved the solution structure of the cold-shock like protein RrCSP isolated from Rikketsia ricketsii through the use of 3-D NMR techniques.

Current Research Project:
Investigating protein-protein interactions between ribosome bound nascent protein chains and ribosomal proteins and/or co-translationally active chaperones.

Hobbies / Interests:
Frisbee golf, ultimate frisbee, running, lifting weights, reading, building computers, cooking, canoeing, drawing

 

Matthew Dalphin

dalphin@wisc.edu

Joined Group:
January, 2015

Education:
B.S. in Biochemistry with honors at California State University, Fullerton

Home Town:
Oceanside, CA

Research before joining the lab:
Identifying novel copper-binding proteins in mammalian blood plasma (Dr. Maria Linder, 2013-2014 CSU Fullerton HHMI Research Scholar). Production and characterization of amyloidogenic human cystatin C. (Dr. Regina Murphy, 2013 Univ. of Wisconsin- Madison Summer Research Program).

Current research Project:
Characterizing the impact of co-translational nascent chain interactions on protein folding.

Hobbies / Interests:
Hiking, Camping, Music, Cooking

  Miranda

Miranda Mecha

mmecha@wisc.edu

Joined Group:
September, 2015

Education:
B.S. in Biochemistry at Carroll University

Home Town:
Milwaukee, Wi

Research before joining the lab:
Record lab: Focused on the mechanism of RNAP’s open complex formation. Studied the FRET kinetics of fluorescently labeled promoters on the stopped-flow instrument and rapid-quench association assays with radioactively labeled DNA using a 3-syringe fast-mixer. Also conducted dissociation assays to determine optimal conditions for hydroxyl-radical footprinting.

Current research Project:

Determining the folded state of SH3 as it is released from DnaK using stopped flow fluorescence and Circular Dichroism (CD) detection.

Hobbies / Interests:
Reading, writing, cooking, and Netflix

 

Hanming Yang

hyang366@wisc.edu

Joined Group:
November, 2016

Education:
B.S. Chemistry, University of Colorado-Boulder, Boulder, CO

Research before joining the lab

High-resolution IR spectroscopy of small, organic radicals

 

Current Project

Sensitivity enhancement in NMR spectroscopy using Photochemically Induced Dynamic Nuclear Polarization (photo-CIDNP)

 

Hobbies / Interests: 

Cycling, Skiing, cat petting

 

Rachel Hutchinson


Joined Group:
November, 2017

Education:
B.S. in Chemistry and Mathematics at Roberts Wesleyan College

Home Town:
Cortland, NY

Research before joining the lab:
-Studied the absorption of CdTe quantum dots onto TiO2 films (Dr. David Watsons's lab, Universiity of Buffalo)
-Compared activities of pyridine-carboxylate iridium catalysts for water oxidation (Dr. Alceo MMacchioni's lab, University of Perugia, Italy)
 

Current Research Project:
Single molecule FRET to study co-translational protein folding on the ribosome.

Hobbies / Interests:
Running and reading

 

Meranda Masse

mmasse@wisc.edu

Joined Group:
November, 2017

Education:
B.S. Chemistry and Environmental Science, Alverno College, Milwaukee, WI

Home Town:
Antioch, Illinois

Previous research before joining the lab:
Studied the relationship between microbial sulfur metabolism and Iron (III) reduction to elucidate the evolutionary history and biodiversity of microbial respiratory systems

Current Project:
Studying the thermodynamic stability of nascent protein chains

Hobbies / Interests: 
My life basically revolves around my dog, but otherwise I like to play volleyball and read in my spare time

 

Clay Thompson

cthompson39@wisc.edu

Joined Group:
November, 2017

Education:
B.S. Chemistry, San Francisco State University, SF, CA

Home Town:
Pacifica, CA

Previous research before joining the lab:
Synthesis of stilbene derivatives 

Current Project:
Preparation of isotopically labeled proteins

Hobbies / Interests:
Hiking, traveling, STEM education

Undergraduate Students

 

Natalie Feider

nfeider@wisc.edu

Joined Group:
January, 2017

Education:

Current research project:

Studying molecular chaperone-mediated protein folding 

 

Hobbies/ Interests outside of lab:

Music, Art, Movies

 

Alex Staikos

staikos@wisc.edu

Joined Group:
January, 2017

Education:

Research before joining lab:

Effects of RNF113a1/a2 expression in N2A cells

 

Current research project:

Purification of fluorophore-labeled tRNA
Hobbies/Interests outside of lab:

Music, running

 

 

Kevin England

kengland@wisc.edu

Joined Group:
January, 2018

Education:

Current Project:

Investigating protein thermostability 

Hobbies / Interests:

Canoeing, backpacking, skiing

 

Anna Allen

ajallen2@wisc.edu

Joined Group:
January, 2019

Education:

Current research project:

Reengineering the E. coli ribosome to reduce inclusion body formation in overexpression conditions. 

Hobbies / Interests:

Running, traveling, music, foreign languages

 

 

 

 

Chelsea Chen

xchen783@wisc.edu

Joined Group:
January, 2019

Education:

Current research project:

Viscosity measurements to study compaction of ribosome-bound nascent peptide chains.

Hobbies / Interests:

Traveling, running, trying new food, calligraphy and photography.

 

 

 

Miriam Engel

mrengel@wisc.edu

Joined Group:
January, 2019

Education:

Current research project:

Using single-molecule FRET to study nascent protein folding on the ribosome.

Hobbies / Interests:

Writing, sketching, video games.