2024
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Li, S., Bhattacharya, S., Chou, C. Y., Chu, M., Chou, S. C., Tonelli, M., Goger, M., Yang, H., Palmer, A. G., & Cavagnero, S. (2024). LC-Photo-CIDNP hyperpolarization of biomolecules bearing a quasi-isolated spin pair: Magnetic-Field dependence via a rapid-shuttling device. Journal of Magnetic Resonance, Vol. 359, p. 107616.
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Masse, M., Guzman-Luna, V., Varela, A. E., Shapla, U., Hutchinson, R. B., Srivastava, A. K., Wei, W., Fuchs, A. M., & Cavagnero, S. (2024). Nascent Chains Derived from a Foldable Protein Sequence Interact with Specific Ribosomal Surface Sites near the Exit Tunnel. Scientific Reports, 14, 12324.
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Masse, M. M., Hutchinson, R., Morgan, C., Allaman, H., Guan, H., Yu, E. W., & Cavagnero, S. (2024). Mapping Protein–Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome–Nascent Globin Complex. ACS Central Science, Vol. 10, pp. 385-401.
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Cavagnero, S. (2024). Biological Helpers at the Molecular Level: Cell Stress, Environmental Factors and Chaperones. Biophysical Society Newsletter, p. 10.
March Issue
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2023
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Eills, J., Budker, D., Cavagnero, S., Chekmenev, E., Elliott, S., Jannin, S., Lesage, A., Matysik, J., Meersmann, T., Prisner, T., Reimer, J., Yang, H., & Koptyug, I. (2023). Spin Hyperpolarization in Modern Magnetic Resonance. Chemical Reviews, 123(4), 1417-1551.
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Addabbo, R., Hutchinson, R., Allaman, H., Dalphin, M., Mecha, M., Liu, Y., Staikos, A., & Cavagnero, S. (2023). Critical Beginnings: Selective Tuning of Solubility and Structural Accuracy of Newly Synthesized Proteins by the Hsp70 Chaperone System. Journal of Physical Chemistry B, 127(18), 3990-4014.
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Li, S., Yang, H., Hofstetter, H., Tonelli, M., & Cavagnero, S. (2023). Magnetic-Field Dependence of LC-Photo-CIDNP in the Presence of Target Molecules Carrying a Quasi-Isolated Spin Pair. Applied Magnetic Resonance, 54(1), 59-75.
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Chen, X., Hutchinson, R., & Cavagnero, S. (2023). Distribution and solvent exposure of Hsp70 chaperone binding sites across the Escherichia coli proteome. Proteins-Structure Function and Bioinformatics, 91(5), 665-678.
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Cavagnero, S., & Schanda, P. (2023). JMR/JMRO/JSB/JSBX Special Issue on the nuclear magnetic resonance of biological systems. Journal of Magnetic Resonance, Vol. 356, p. 107562.
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Cavagnero, S. (2023). Emerging Tools in Biophysics: Stem Cells, Organoids and Bioprinting. Biophysical Society Newsletter, p. 12.
January Issue
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2022
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Yang, H., Li, S., Mickles, C., Guzman-Luna, V., Sugisaki, K., Thompson, C., Dang, H., & Cavagnero, S. (2022). Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration. Journal of the American Chemical Society, 144(26), 11608-11619.
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Mecha, M. F., Hutchinson, R. B., Lee, J. H., & Cavagnero, S. (2022). Protein folding in vitro and in the cell: From a solitary journey to a team effort. Biophysical Chemistry, Vol. 287.
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Guzman-Luna, V., & Cavagnero, S. (2022). Mg2+ ions mediate the interaction of intrinsically disordered nascent chains with the ribosome implications for protein folding and aggregation in the early stages of protein life (Vol. 3, pp. 3-5). Vol. 3, pp. 3-5.
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Bondos, S., & Cavagnero, S. (2022). Regaining and Preserving Wellness during and after the COVID-19 Pandemic. Biophysical Society Newsletter, p. 11.
May Issue
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Cavagnero, S. Understanding and Curing Deadly Proteinopathies by Harnessing the Power of Biophysics. Biophysical Society Newsletter, p. 16.
January Issue
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2021
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Yang, H., Mecha, M., Goebel, C., & Cavagnero, S. (2021). Enhanced nuclear-spin hyperpolarization of amino acids and proteins via reductive radical quenchers. Journal of Magnetic Resonance, 324.
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Hutchinson, R., Chen, X., Zhou, N., & Cavagnero, S. (2021). Fluorescence Anisotropy Decays and Microscale-Volume Viscometry Reveal the Compaction of Ribosome-Bound Nascent Proteins. Journal of Physical Chemistry B, 125(24), 6543-6558.
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Guzman-Luna, V., Fuchs, A., Allen, A., Staikos, A., & Cavagnero, S. (2021). An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel. Communications Biology, 4(1).
2020
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Yaeger-Weiss, S., Jennaro, T., Mecha, M., Becker, J., Yang, H., Winkler, G., & Cavagnero, S. (2020). Net Charge and Nonpolar Content Guide the Identification of Folded and Prion Proteins. Biochemistry, 59(20), 1881-1895.
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Thompson, C., McDonald, A., Yang, H., Cavagnero, S., & Buller, A. (2020). Modular control ofl-tryptophan isotopic substitutionviaan efficient biosynthetic cascade. Organic & Biomolecular Chemistry, 18(22), 4189-4192.
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Lee, J., Park, S., Cavagnero, S., & Lee, J. (2020). High-Resolution Diffusion Measurements of Proteins by NMR under Near-Physiological Conditions. Analytical Chemistry, 92(7), 5073-5081.
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Dalphin, M., Stangl, A., Liu, Y., & Cavagnero, S. (2020). KLR-70: A Novel Cationic Inhibitor of the Bacterial Hsp70 Chaperone. Biochemistry, 59(20), 1946-1960.
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Addabbo, R., Dalphin, M., Mecha, M., Liu, Y., Staikos, A., Guzman-Luna, V., & Cavagnero, S. (2020). Complementary Role of Co- and Post-Translational Events in De Novo Protein Biogenesis. Journal of Physical Chemistry B, 124(30), 6488-6507.
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Cavagnero, S. Celebrating Science Wizardry and Protein Design. Biophysical Society Newsletter, 13.
December Issue
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2019
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Yang, H., Hofstetter, H., & Cavagnero, S. (2019). Fast-pulsing LED-enhanced NMR: A convenient and inexpensive approach to increase NMR sensitivity. Journal of Chemical Physics, 151(24), 245102.
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Yang, H., & Cavagnero, S. (2019). Improved sensitivity of laser-enhanced 1Hα-13Cα-correlation via suppression of Cα-C’ scalar-coupling evolution. Journal of Magnetic Resonance, 307.
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Varela, A., England, K., & Cavagnero, S. (2019). Kinetic trapping in protein folding. Protein Engineering, Design and Selection, 32(2), 103-108.
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Okuno, Y., Mecha, M., Yang, H., Zhu, L., Fry, C., & Cavagnero, S. (2019). Laser- and cryogenic probe-assisted NMR enables hypersensitive analysis of biomolecules at submicromolar concentration. Proceedings of the National Academy of Sciences of the United States of America, 116(24), 11602-11611.
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Cavagnero, S. (2019). Exploring Biology and Embracing Diversity at SACNAS. Biophysical Society Newsletter, p. 11.
December Issue
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2018
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Varela, A., Lang, J., Wu, Y., Dalphin, M., Stangl, A., Okuno, Y., & Cavagnero, S. (2018). Kinetic Trapping of Folded Proteins Relative to Aggregates under Physiologically Relevant Conditions. Journal of Physical Chemistry B, 122(31), 7682-7698.
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Okuno, Y., & Cavagnero, S. (2018). Effect of heavy atoms on photochemically induced dynamic nuclear polarization in liquids. Journal of Magnetic Resonance, 286, 172-187.
2017
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Okuno, Y., & Cavagnero, S. (2017). Photochemically induced dynamic nuclear polarization: Basic principles and applications. EMagRes, 6(2), 283-314.
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Carlson, T., Lam, K., Lam, C., He, J., Maynard, J., & Cavagnero, S. (2017). Naked-Eye Detection of Reversible Protein Folding and Unfolding in Aqueous Solution. Journal of Chemical Education, 94(3), 350-355.
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Cavagnero, S. (2017). A Prize for Going in Vivo. Biophysical Society Newsletter, p. 16.
January Issue
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2016
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Okuno, Y., & Cavagnero, S. (2016). Fluorescein: A Photo-CIDNP Sensitizer Enabling Hypersensitive NMR Data Collection in Liquids at Low Micromolar Concentration. Journal of Physical Chemistry B, 120(4), 715-723.
2015
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Lee, J., Zhang, D., Hughes, C., Okuno, Y., Sekhar, A., & Cavagnero, S. (2015). Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone. Proceedings of the National Academy of Sciences of the United States of America, 112(31), E4206-E4215.
2014
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Lee, J., Okuno, Y., & Cavagnero, S. (2014). Sensitivity enhancement in solution NMR: Emerging ideas and new frontiers. Journal of Magnetic Resonance, 241, 18-31.
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Jennaro, T., Beaty, M., Kurt-Yilmaz, N., Luskin, B., & Cavagnero, S. (2014). Burial of nonpolar surface area and thermodynamic stabilization of globins as a function of chain elongation. Proteins Structure Function & Bioinformatics, 82(10), 2318-2331.
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Fedyukina, D., Jennaro, T., & Cavagnero, S. (2014). Charge Segregation and Low Hydrophobicity Are Key Features of Ribosomal Proteins from Different Organisms. Journal of Biological Chemistry, 289(10), 6740-6750.
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Cavagnero, S. (2014). Fascinated by Live Cells. Biophysical Society Newsletter, p. 16.
November Issue
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Gierasch, L., Cavagnero, S., & Gruebele, M. (2014). Biophysics in the cell comes alive at the BIV symposium. Biophysical Society Newsletter, pp. 10-11.
April Issue
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2013
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Zhu, L., Kurt, N., Choi, J., Lapidus, L., & Cavagnero, S. (2013). Sub-millisecond Chain Collapse of the Escherichia coli Globin ApoHmpH. Journal of Physical Chemistry B, 117(26), 7868-7877.
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Lee, J., & Cavagnero, S. (2013). A Novel Tri-Enzyme System in Combination with Laser-Driven NMR Enables Efficient Nuclear Polarization of Biomolecules in Solution. Journal of Physical Chemistry B, 117(20), 6069-6081.
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Knight, A., Culviner, P., Kurt-Yilmaz, N., Zou, T., Ozkan, S., & Cavagnero, S. (2013). Electrostatic Effect of the Ribosomal Surface on Nascent Polypeptide Dynamics. ACS Chemical Biology, 8(6), 1195-1204.
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Wittung-Stafshede, P., Gierasch, L., & Cavagnero, S. (2013). BIV Subgroup Takes Exciting Journey Through in vivo Biophysics. Biophysical Society Newsletter, p. 7.
April Issue
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2012
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Sekhar, A., Santiago, M., Lam, H., Lee, J., & Cavagnero, S. (2012). Transient interactions of a slow-folding protein with the Hsp70 chaperone machinery. Protein Science, 21(7), 1042-1055.
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Sekhar, A., Lam, H., & Cavagnero, S. (2012). Protein folding rates and thermodynamic stability are key determinants for interaction with the Hsp70 chaperone system. Protein Science, 21(10), 1489-1502.
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Cavagnero, S., & Mukerjee, I. (2012). Getting Places Together: How to Find and Keep a Good Mentor. Biophysical Society Newsletter, pp. 6-7.
April Issue
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2011
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Rajagopalan, S., Kurt, N., & Cavagnero, S. (2011). High-Resolution Conformation and Backbone Dynamics of a Soluble Aggregate of Apomyoglobin(119). Biophysical Journal, 100(3), 747-755.
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Lee, J., Sekhar, A., & Cavagnero, S. (2011). H-1-Detected C-13 Photo-CIDNP as a Sensitivity Enhancement Tool in Solution NMR. Journal of the American Chemical Society, 133(21), 8062-8065.
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Fedyukina, D., & Cavagnero, S. (2011). Protein Folding at the Exit Tunnel. Annual Review of Biophysics, 40, 337-359.
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Armstrong, B., Choi, J., Lopez, C., Wesener, D., Hubbell, W., Cavagnero, S., & Han, S. (2011). Site-Specific Hydration Dynamics in the Nonpolar Core of a Molten Globule by Dynamic Nuclear Polarization of Water. Journal of the American Chemical Society, 133(15), 5987-5995.
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Kurt, N., Mounce, B., Ellison, P., & Cavagnero, S. (2011). Residue-specific contact order and contact breadth in single-domain proteins: implications for folding as a function of chain elongation. Biotechnology Progress, Vol. 28, pp. 297-297.
Erratum
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2010
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Ziehr, D., Ellis, J., Culviner, P., & Cavagnero, S. (2010). Production of Ribosome-Released Nascent Proteins with Optimal Physical Properties. Analytical Chemistry, 82(11), 4637-4643.
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Weinreis, S., Ellis, J., & Cavagnero, S. (2010). Dynamic fluorescence depolarization: A powerful tool to explore protein folding on the ribosome. Methods, 52(1), 57-73.
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Fedyukina, D., Rajagopalan, S., Sekhar, A., Fulmer, E., Eun, Y.-J., & Cavagnero, S. (2010). Contribution of Long-Range Interactions to the Secondary Structure of an Unfolded Globin. Biophysical Journal, 99(5), L37-L39.
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Ellis, J., Culviner, P., & Cavagnero, S. (2010). Confined dynamics of a ribosome-bound nascent globin: Cone angle analysis of fluorescence depolarization decays in the presence of two local motions. Protein Science, Vol. 19, p. 1600.
Erratum
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2009
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Sekhar, A., & Cavagnero, S. (2009). H-1 Photo-CIDNP Enhancements in Heteronuclear Correlation NMR Spectroscopy. Journal of Physical Chemistry B, 113(24), 8310-8318.
Erratum
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Sekhar, A., & Cavagnero, S. (2009). EPIC- and CHANCE-HSQC: Two N-15-photo-CIDNP-enhanced pulse sequences for the sensitive detection of solvent-exposed tryptophan. Journal of Magnetic Resonance, 200(2), 207-213.
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Ellis, J., Culviner, P., & Cavagnero, S. (2009). Confined dynamics of a ribosome-bound nascent globin: Cone angle analysis of fluorescence depolarization decays in the presence of two local motions. Protein Science, 18(10), 2003-2015.
2008
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Mounce, B., Kurt, N., Ellison, P., & Cavagnero, S. (2008). Nonrandom distribution of intramolecular contacts in native single-domain proteins. Proteins Structure Function & Bioinformatics, 75(2), 404-412.
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Kurt, N., Mounce, B., Ellison, P., & Cavagnero, S. (2008). Residue-specific contact order and contact breadth in single-domain proteins: Implications for folding as a function of chain elongation. Biotechnology Progress, 24(3), 570-575.
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Kurt, N., & Cavagnero, S. (2008). Nonnative helical motif in a chaperone-bound protein fragment. Biophysical Journal, 94(7), L48-L50.
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Eun, Y.-J., Kurt, N., Sekhar, A., & Cavagnero, S. (2008). Thermodynamic and kinetic characterization of apoHmpH, a fast-folding bacterial globin. Journal of Molecular Biology, 376(3), 879-897.
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Ellis, J., Bakke, C., Kirchdoerfer, R., Jungbauer, L., & Cavagnero, S. (2008). Chain dynamics of nascent polypeptides emerging from the ribosome. ACS Chemical Biology, 3(9), 555-566.
2007
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Kirchdoerfer, R., Huang, J., Isola, M., & Cavagnero, S. (2007). Fluorescence-based analysis of aminoacyl- and peptidyl-tRNA by low-pH sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Analytical Biochemistry, 364(1), 92-94.
2006
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Vega, C., Kurt, N., Chen, Z., Rudiger, S., & Cavagnero, S. (2006). Binding specificity of an alpha-helical protein sequence to a full-length Hsp70 chaperone and its minimal substrate-binding domain. Biochemistry, 45(46), 13835.
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Kurt, N., Rajagopalan, S., & Cavagnero, S. (2006). Effect of Hsp70 chaperone on the folding and misfolding of polypeptides modeling an elongating protein chain. Journal of Molecular Biology, 355(4), 809-820.
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Jungbauer, L., & Cavagnero, S. (2006). Characterization of protein expression and folding in cell-free systems by MALDI-TOF mass spectrometry. Analytical Chemistry, 78(8), 2841-2852.
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Jungbauer, L., Bakke, C., & Cavagnero, S. (2006). Experimental and computational analysis of translation products in apomyoglobin expression [Review]. Journal of Molecular Biology, 357(4), 1121-1143.
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Ellison, P., & Cavagnero, S. (2006). Role of unfolded state heterogeneity and en-route ruggedness in protein folding kinetics. Protein Science, 15(3), 564-582.
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Chow, C., Kurt, N., Murphy, R., & Cavagnero, S. (2006). Structural characterization of apomyoglobin self-associated species in aqueous buffer and urea solution. Biophysical Journal, 90(1), 298-309.
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Chen, Z., Kurt, N., Rajagopalan, S., & Cavagnero, S. (2006). Secondary structure mapping of DnaK-bound protein fragments: Chain helicity and local helix unwinding at the binding site. Biochemistry, 45(40), 12325.
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Cavagnero, S., & Kurt, N. (2006). Folding and misfolding as a function of polypeptide chain elongation: Conformational trends and implications for intracellular events. Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability, 217-245.
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Bakke, C., Jungbauer, L., & Cavagnero, S. (2006). In vitro expression and characterization of native apomyoglobin under low molecular crowding conditions. Protein Expression & Purification, 45(2), 381-392.
2005
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Kurt, N., & Cavagnero, S. (2005). The burial of solvent-accessible surface area is a predictor of polypeptide folding and misfolding as a function of chain elongation. Journal of the American Chemical Society, 127(45), 15690-15691.
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Cavagnero, S., & Jungbauer, L. (2005). Painting protein misfolding in the cell in real time with an atomic-scale brush [Review]. Trends in Biotechnology, 23(3), 157-162.
2004
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Rajagopalan, S., Chow, C., Raghunathan, V., Fry, C., & Cavagnero, S. (2004). NMR spectroscopic filtration of polypeptides and proteins in complex mixtures. Journal of Biomolecular NMR, 29(4), 505-516.
2003
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Chow, C., Chow, C., Raghunathan, V., Huppert, T., Kimball, E., & Cavagnero, S. (2003). Chain length dependence of apomyoglobin folding: Structural evolution from misfolded sheets to native helices. Biochemistry, 42(23), 7090-7099.
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Cavagnero, S. (2003). Using NMR to determine protein structure in solution. Journal of Chemical Education, 80(2), 125-127.