July 2020

Rayna and coworkers published a cover article in the Jounal of Physical Chemistry B showing that the bacterial ribosome enhances nascent-protein solubility but it is not sufficient to guarantee full structural accuracy of de-novo synthesized (and ribosome-released) proteins. This work also shows that kinetic channeling upon release from the ribosome is very sensitive to the amino acid sequence of nascent proteins. So, even single-point mutations that do not alter the structure and thermodynamic stability of the native state can have a dramatic effect on the yield of soluble and insoluble aggregate formation upon release from the ribosome. Cool results, Rayna and friends!!!  yes